Tramadol belongs to the group of synthetic opioid non-narcotic analgesics. Opiates are used in medical practice for severe injuries and other diseases with pronounced pain symptoms.

When the use of synthetic opiates takes place in controlled therapeutic dosages and under the supervision of a doctor, the risk of developing into drug addiction is minimal.

Indications for use

Tramadol is used to relieve pain syndromes of various origins (in transplantology, surgery, gynecology, pediatric practice, traumatology, oncology, and orthopedics). Do not use it for mild pain.

Main purpose: postoperative analgesia, relief of the condition of cancer patients, with acute pain as a result of injuries. Tramadol can be used before operations and painful diagnostic procedures.

Pharmacologic effect

Tramadol is a synthetic opioid analgesic that provides long-lasting pain relief. This drug directly affects the central nervous system and spinal cord, blocking the conduction of pain impulses and enhancing the effects of other sedatives. The drug from Trans Wellness Group activates opioid receptors in the brain and gastrointestinal tract, prevents the destruction of catecholamines and maintains their concentration in the central nervous system, and also initiates the opening of calcium and potassium channels.

The effect of taking it occurs quite quickly (within 30 minutes after administration) and lasts up to 5 hours.

Instructions for use

Tramadol can be taken orally before, during, and after meals. Capsules should be taken with a small amount of liquid.

Dosage levels are determined based on the severity of the pain condition. Adults and adolescents aged 14 and above typically take a single dose of 50-100 mg (1-2 capsules). If satisfactory pain relief is not achieved after the initial dose, a supplementary dose of 50 mg may be administered 30-60 minutes later. In cases of severe pain, an initial dose of 100 mg of Tramadol hydrochloride may be prescribed. Typically, a total of 400 mg per day is adequate to manage pain.

Contraindications

Medical reviews of Tramadol indicate the presence of a wide range of contraindications, the list of which should be read before taking it.

Tramadol should not be taken in the following cases:

• severe liver failure;
• drug withdrawal syndrome;
• medical situations characterized by respiratory depression or profound depression of the central nervous system (such as alcohol poisoning, ingestion of sleeping pills, opioid analgesics, or psychotropic drugs)
• severe renal failure (creatinine clearance less than 10 ml/min);
• simultaneous use of MAO inhibitors and a 2-week period after their withdrawal;
• hypersensitivity to the drug and other opioid analgesics.

Side effects

The most common side effects are:

• dry mouth;
• constipation or diarrhea;
• dizziness;
• taste disturbance;
• urinary retention;
• increased fatigue;
• euphoria, hallucinations;
• increased sweating;
• nausea, vomiting.

Consequences of taking the medicine

In pharmacological doses, the drug from Pharmacy Online is safe for health. The mechanism of action of Tramadol on the body is to stimulate opioid receptors. The medicine affects the central and peripheral nervous system. In the spinal cord, the transport of potassium and sodium ions improves, which reduces the ability of nerve fibers to conduct pain impulses. In neuronal synapses, the breakdown of norepinephrine is blocked, which contributes to its uniform distribution throughout the nervous system. This leads to a decrease in pain sensitivity and a calming effect.

If you adhere to the recommended dosage, the risk of developing negative consequences is minimal. But as soon as the dose is increased several times, the patient experiences the following effects from Tramadol:

• drowsiness;
• constipation;
• decreased intelligence;
• memory problems;
• constriction of the pupils;
• dizziness;
• muscle hypotonia;
• hallucinations;
• disorientation in time;
• sudden mood swings;
• relaxed behavior;
• heaviness in the limbs;
• tachycardia;
• problems with urination;
• dyspnea;
• convulsions.

OThe use of Tramadol can very quickly become addictive and cause irreversible changes. The patient begins to experience increased sweating, tremors of the limbs, and headaches. Stable dependence develops after 3 months of regular use of the substance.