Prednisone is a hormonal glucocorticoid drug widely used in medical practice due to its strong anti-inflammatory and antiallergic properties.

This synthetic corticosteroid is derived from prednisone, a substance similar to the hormone cortisol produced by the adrenal glands. Prednisone has a pharmacological effect similar to cortisol but with more pronounced anti-inflammatory activity and an increased duration of action. These advantages of prednisone allow for low dosage and once-daily dosing frequency, reducing side effects while maintaining the effectiveness of therapy.

Indications for use

The drug prednisone can be used in various fields of medicine. It is used in the following cases:

• Inflammatory and allergic diseases caused by the body's immune reactions, such as bronchial asthma, rhinitis, dermatitis, allergic conjunctivitis;
• Rheumatic diseases such as rheumatoid arthritis, gout, rheumatic fever;
• Systemic connective tissue diseases, such as systemic lupus erythematosus, dermatomyositis;
• Autoimmune skin lesions such as psoriasis, eczema, lichen planus;
• Chronic intestinal diseases such as ulcerative colitis, Crohn's disease;
• Hormonal disorders and adrenal hyperplasia;
• Malignant tumors such as leukemia, lymphoma;
• Tumors of the brain and spinal cord;
• Vascular and hemostasis disorders, such as thrombocytopenia, hemolytic anemia;
• Disorders of organs and systems, such as pneumonia, meningitis, glomerulonephritis;
• Organ transplantation to suppress immune responses;
• Diffuse connective tissue diseases;
• Suppression of immune reactions during the transfer of blood and organs;
• Arterial hypertension;
• Hormonal disorders in children (as prescribed by a doctor).

Time of receipt

Prednisone tablets are usually taken once a day in the morning. Taking pills in the morning corresponds to the natural production of cortisol in the body, simulating its normal cycle. Cortisol levels are usually highest in the morning and gradually decrease throughout the day. However, some patients may be directed to split the dose and take it twice daily.

Prednisone is usually recommended with or immediately after meals to prevent gastrointestinal irritation. Food or milk minimizes direct contact of Prednisone with the gastric mucosa, which helps reduce the risk of indigestion and ulcerative changes.

Contraindications

Contraindications to the use of the drug Prednisone can be divided into absolute and relative. Absolute contraindications mean that the drug is strictly prohibited from use since its use can lead to serious consequences for the patient. Relative contraindications, in turn, mean that the use of the drug from /trans-wellness-pharmacy/ is possible, but special attention and caution are required.

Absolute contraindications to the use of Prednisone include:

• Infectious diseases caused by viruses, fungi, or bacteria;
• Cardiovascular disorders;
• Hormone-dependent disease, such as Cushing's syndrome;
• Children under two years old;
• Pregnancy and breastfeeding;
• Acute pancreatitis;
• Gastric or duodenal ulcer;
• Incurable liver and kidney dysfunctions;
• Acute mental disorders;

Relative contraindications to the use of Prednisone include:

• Diabetes mellitus;
• Severe infectious diseases;
• Acute and chronic renal dysfunction;
• Diseases of the stomach and intestines;
• Acute mental and neurological disorders;
• Thyroid gland dysfunction;
• Acute eye infections;
• Angiofibrosis due to Prednisone.

If there are contraindications to the use of the drug Prednisone, you must first consult with a doctor who can indicate the existing risks and select the appropriate therapy for each patient.